The South Americans, who won all three of their first round games to top their group, have so far been the impressive of the two and are the only team yet to concede goal at the tournament in Russian Federation.
Since Uruguay and Portugal have not faced each other since a friendly match in 1972, Cristiano Ronaldo hasn't had the chance to take on Suarez and Cavani together, but he has done it separately and scored more than both.
Suarez and Cavani have both found the net in three consecutive World Cups, and they have five goals between them here in Russian Federation.
Messi provided two assists as Argentina were beaten in a thrilling match in Kazan but he has now appeared in the knockout stages of four World Cups and failed to score in any of them.
Only one can advance, and Portugal needs to play better than it did in tying Spain and Iran.
With four goals from his first three games, the Real Madrid star has been living up to his pre-tournament hype.
At 33, Ronaldo is still the most important player in Fernando Santos's team, but it really is a case that if you stop Ronaldo, you beat Portugal.
This was a big win for Uruguay, but it was also an important victory for South America considering the European dominance of this World Cup so far. "We've improved in possession thanks to the younger players but we haven't lost that commitment, that fight, the sacrifice and solidarity, the determination to overcome adversity". He became a FIFA-graded referee in 2014 and this would be his first World Cup.
It was a five-pass buildup from deep in its own end that culminated in Uruguay's first goal, and the final two passes were ideal. It was two weeks ago that Ronaldo scored a hat trick in the same stadium against Spain, stroking his chin after the first goal to imply he was the "greatest of all time". While Uruguay have looked fairly confident despite wins in slender margins, Portugal scraped past in their final group stage outing against Iran.
"I don't know what the match will be like", he said.
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